![]() ![]() Comparative analysis based on alignments of these sequences is one powerful tool for interpreting such genomic information. ![]() 1999) genomes are fueling a major revolution in the biological sciences ( Lander 1996). 1998 Marshall 1999) and mouse ( Battey et al. The availability of complete sequences of many microbial genomes and the proposed sequencing of the human ( Collins et al. PipMaker supports analysis of unfinished or “working draft” sequences by permitting one of the two sequences to be in briggsae, or Escherichia coli and Salmonella spp. Million years ago, such as humans and mice, Caenorhabditis elegans and C. Gene regulatory elements are often detectable as similar, noncoding sequences in species that diverged as much as 100–300 PipMaker is appropriate for comparing genomic sequences from any two related species,Īlthough the types of information that can be inferred (e.g., protein-coding regions and cis-regulatory elements) depend on the level of conservation and the time and divergence rate since the separation of the species. The web site also provides a plot of the locations of those segments Positions along the horizontal axis can be labeled with features such as exons of genes and repetitive elements, andĬolors can be used to clarify and enhance the display. ![]() In one sequence and the degree of similarity for each aligning segment between the two sequences in a compact and easily understandableįorm. One display is a percent identity plot (pip), which shows both the position High-resolution displays of the resulting alignments. PipMaker ( ) is a World-Wide Web site for comparing two long DNA sequences to identify conserved segments and for producing informative, ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |